Roseanne Barr
as Roseanne Conner
John Goodman
as Dan Conner
Laurie Metcalf
as Jackie Harris
Sara Gilbert
as Darlene Conner
Michael Fishman
as D.J. Conner
Lecy Goranson
as Becky Conner
Sarah Chalke
as Becky Conner
Ames McNamara
as Mark Conner-Healy
Emma Kenney
as Harris Conner-Healy
Jayden Rey
as Mary Conner
Natalie West
as Crystal Anderson
Johnny Galecki
as David Healy
Glenn Quinn
as Mark Healy