Damon Wayans
as Detective Roger Mayfield Murtaugh
Keesha Sharp
as Trish Murtaugh
Kevin Rahm
as Captain Brooks Avery
Michelle Mitchenor
as Detective Sonya Bailey
Johnathan Fernandez
as Scorsese
Clayne Crawford
as Detective Martin Riggs
Jordana Brewster
as Dr. Maureen "Mo" Cahill
Chandler Kinney
as Riana Murtaugh
Dante Brown
as Roger Murtaugh, Jr.
Seann William Scott
as Wesley Cole