Dominic Cooper
as Jesse Custer
Ruth Negga
as Tulip O'Hare
Joseph Gilgun
as Cassidy
Ian Colletti
as Eugene "Arseface" Root
Graham McTavish
as The Saint of Killers
Julie Ann Emery
as Lara Featherstone
Pip Torrens
as Klaus Helmut Starr
Noah Taylor
as Adolf Hitler
Malcolm Barrett
as FJ Hoover
Mark Harelik
as God
Tyson Ritter
as Humperdoo
Tom Brooke
as Fiore
Betty Buckley
as Gran'ma
W. Earl Brown
as Sheriff Hugo Root
Lucy Griffiths
as Emily Woodrow
Colin Cunningham
as T.C.
Derek Wilson
as Donnie Schenck
Anatol Yusef
as DeBlanc